New Drug Derivatives for Promoting Oral Delivery to the Lung

Technology Description

A series of novel lipid derivatives of phosphonate compounds has been synthesized. These novel compounds have been shown to promote oral uptake and increase delivery of the conjugate to the lung in animal models when compared with the parent compounds. A similar derivatization strategy can also be applied to non-phosphonate compounds making this approach applicable to a variety of existing drugs.

Drugs that have been modified in this way will very likely be more effective against diseases of the lung and this approach has the potential to improve the efficacy of drugs that are directed against pulmonary infections, such as influenza, or lung diseases, such as cancer.

Patent Status